INDICATORS ON PKRRATING YOU SHOULD KNOW

dPKR kinase domain phosphorylated on residue T446 similar to chain B with the PKR kinase – eIF2α crystal framework PDB ID 2A19. seventeen autophosphorylation at T466 is not possible In this particular geometry plus the docking web-site on helix αG for the substrate eIF2α is blocked. nevertheless, equivalent interfaces making use of the αEF a